Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
EN106
CAS: 757192-67-9
Molecular Formula: C13H13ClN2O3
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- - Names and Identifiers
| Name | EN106 |
| Synonyms | EN106 Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- |
| CAS | 757192-67-9 |
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- - Physico-chemical Properties
| Molecular Formula | C13H13ClN2O3 |
| Molar Mass | 280.71 |
| Density | 1.351±0.06 g/cm3(Predicted) |
| Boling Point | 489.1±45.0 °C(Predicted) |
| pKa | 0.42±0.20(Predicted) |
| Storage Condition | -20℃ |
| Use | EN106 is a potent FEMIB inhibitor. EN106 is a cysteine reactive covalent ligand. EN106 destroys the identification of key reducing stress substrates for FEM1B, FNIP1. |
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- - Reference
| Reference Show more | 1. Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. |
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.562 ml | 17.812 ml | 35.624 ml |
| 5 mM | 0.712 ml | 3.562 ml | 7.125 ml |
| 10 mM | 0.356 ml | 1.781 ml | 3.562 ml |
| 5 mM | 0.071 ml | 0.356 ml | 0.712 ml |
Last Update：2024-01-02 23:10:35
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